a16z AI Application Spending Report

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 a16z’s AI Spending Report

 Where Startups Are Secretly Pouring Their AI Dollars

Startups aren’t just adopting AI—they’re reorganizing around it. Andreessen Horowitz (a16z), in partnership with Mercury, analyzed spend from 200k+ startups to reveal the top 50 AI-native applications shaping the future of work.

Key insights:

 Horizontal apps dominate — 60% of spend goes to productivity tools usable across roles (OpenAI, Anthropic, Notion, Canva).

 Creative tools surge — Image, video, and voice apps (Freepik, ElevenLabs, Midjourney, Descript) now span beyond marketing into everyday workflows.

 Vertical AI is splitting — Most augment human roles, but a growing set (Cognition, 11x, Serval) act as AI “employees.”

 Vibe coding rises — Platforms like Replit and Cursor are powering agentic app development at scale.

 Consumer-to-enterprise shift — Nearly 70% of companies started as consumer-first, now expanding into enterprise-grade adoption.

The report is a real-time signal of how AI is reshaping work—and where capital is flowing.

Explore the full a16z AI Application Spending Report here.

⚡ 3 VC Shifts Changing Startup Fundraising

 September VC Trends: The Shifts Founders Can’t Ignore

Over $4B was raised by VC funds in September, with 40+ new funds launched. But the real story is who raised—and how they’re deploying.

Key trends reshaping the landscape:

1️⃣ Corporate Venture Comeback

• Sanofi: $625M biotech fund as traditional checks slowed
• CoreWeave: Pairing compute with capital
• Robinhood: Filed for a retail-accessible NYSE-listed fund

2️⃣ Healthcare Specialists Dominate

• 28% of new funds targeted healthcare
• Extreme subspecialization—from women’s health to AI-driven biotech

3️⃣ Europe’s Share Is Growing

• 31% of funds were Europe-based
• US led at 46%, but capital is spreading beyond Silicon Valley

A fund to watch: Standard Capital ($425M inaugural fund), founded by Paul Buchheit, Dalton Caldwell, and Bryan Berg, reinventing Series A with:

• Fast decisions & standardized terms
• No board seats, no legal fees
• Founder-set valuations and round sizes
• Open applications—no warm intro needed
• AI-native diligence

Corporate venture, healthcare specialization, and AI-native processes are rewriting how capital flows.

Explore the full September VC trend report here.

✨ And here’s the part founders should really pay attention to: knowing *where the money is flowing is one thing—but knowing who writes the first checks is another. There’s a list of 1,000+ active angel investors making early bets that never show up in VC reports. It might be the edge you didn’t know you needed.

 Why Startups Are Demanding 70+ Hour Weeks

 996 Is Back—Are Founders Ready?

A work culture once outlawed in China is resurfacing in Silicon Valley: 996 — working 9 a.m. to 9 p.m., six days a week. That’s 72 hours, every week.

Key insights from recent reports:

 Rooted in China’s tech boom — companies like Alibaba and Huawei fueled rapid growth with 996 before it was made illegal in 2021.
 Resurfacing in AI startups — firms like Rilla and Cognition are openly advertising 70–80 hour weeks.
 Leaders pushing limits — Google co-founder Sergey Brin suggested 60 hours as the “sweet spot of productivity.”
 Economic backdrop — layoffs (400,000+ since 2022) may be driving workers to accept harsher schedules for job security.
 Cultural shift — Ramp data shows more corporate spend on Saturdays in San Francisco, suggesting weekend work is rising.

Silicon Valley is reviving a work culture many considered extreme. Is this discipline driving innovation—or a step backward for work-life balance?

Read the full story and share your perspective.

 Perplexity’s Comet: The AI Browser Goes Free

Perplexity Launches Comet Browser Worldwide

Perplexity AI has released its AI-powered Comet browser for free global download as of October 2, 2025—ending exclusivity for premium subscribers and opening access to millions on the waitlist.

Key highlights:

 AI-native browsing — built on Chromium, integrates agents to summarize pages, organize tabs, and automate tasks
 Productivity boost — supports drafting emails and simplifying workflows like online shopping
 Premium tier — Comet Plus (for Pro & Max subscribers) offers ad-free browsing and access to partner news from The Washington Post, CNN, and more

Comet signals a shift toward browsers as AI-driven productivity hubs, not just gateways to the web. Explore the full launch details here.

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Nvidia’s $100B Bet on OpenAI

 Nvidia + OpenAI: A $100B Power Play

Two of the biggest names in AI are joining forces. Nvidia plans to invest up to $100 billion in OpenAI, while also supplying advanced chips to power its next wave of AI breakthroughs.

Key highlights:

 Dual structure deal — Nvidia to provide non-voting shares + OpenAI to reinvest capital in Nvidia chips
 Massive compute scale — at least 10 gigawatts of Nvidia systems for OpenAI, equal to powering 8M+ U.S. homes
 Strategic timing — first hardware deployments expected in 2026 on Nvidia’s new Vera Rubin platform
 Industry impact — could tighten Nvidia’s chip dominance and reinforce OpenAI’s software leadership
 Concerns raised — analysts note risks of “circular” investments and potential antitrust scrutiny

This alliance underscores how compute has become the new foundation of AI’s economy.

Will Nvidia’s stake in OpenAI reshape the competitive balance—or fuel concerns of consolidation in AI? Read the full breakdown here.

 Startups Buzz

How to Build an MVP (YC Style)

YC’s Michael Seibel breaks down the essentials of building a minimum viable product. From defining the core feature set to creating prototypes and testing with real users, this guide shows how the best startups keep things simple while moving fast.

Watch the full session here.

MVP: Not Bike-to-Car

The classic “skateboard-to-car” MVP diagram misses the point. Fred Voorhorst explains why building a sequence of focused prototypes—sometimes even without full tech—is the real path to validating UX and product fundamentals.

Read the full breakdown here.

⚡ Best Startup Tools to Build & Scale

From idea to growth stage, choosing the right tools can make or break a startup. Explore curated picks for building, running, and scaling efficiently without wasting time or capital.

Explore the list here.

 What Is an MVP, Really?

Venture Hacks defines a Minimum Viable Product as the product with the best ROI vs. risk. Learn why keeping features fundamental—and iterating relentlessly—makes the MVP the foundation of startup success.

Read the full article here.

 How AI Founders Are Building MVPs

AI startup founders are rethinking MVPs. Some strip features down to the bare minimum, others simulate UX with “Wizard of Oz” hacks. The Reddit thread reveals raw, practical insights straight from builders.

Dive into the discussion here.

 WEB PICKS

‍  Anthropic’s Surprise CTO Hire Signals Big AI Shift
The new CTO is tasked with scaling Anthropic’s AI infrastructure—hinting at major moves in the foundation model race.

 OpenAI’s Sora Rockets to Top 3 in App Store
After launch, Sora quickly climbed U.S. charts, signaling explosive demand for AI-powered video creation.

 Meet Tinker: Fine-Tune AI From Your Laptop
Thinky’s new tool lets anyone write Python training loops locally, while distributed GPUs handle the heavy lifting (waitlist only for now).

 Waymo’s Robotaxis Cleared for NYC Until 2025
Eight vehicles will keep testing across Manhattan and Brooklyn—human safety drivers still required.

 OpenAI Locks $500B Chip Deal With Samsung + SK Hynix
Agreements secure 900,000 HBM chips monthly—nearly 40% of global DRAM—for the massive Stargate project.

 Meta Will Use Your AI Chats for Ads
Starting Dec 2025, Meta will harvest chatbot conversations for targeting—1B+ users affected, with no opt-out in most regions.

⚡ Salesforce Unveils Agentforce Vibes: Apps From a Prompt
The platform turns natural language into enterprise-grade apps using “vibe coding,” promising to reshape how businesses build software.

Wikipedia Goes Vector: 120M Entries Reimagined for AI
Wikimedia Deutschland transforms Wikipedia into a massive AI-friendly semantic database—opening new frontiers for training data.